Stereoselective Access to Spiro-isoindolinone Scaffolds\nvia Catalytic Asymmetric aza-Piancatelli Rearrangement

A chiral\nBrønsted acid catalyzed asymmetric aza-Piancatelli\nrearrangement of 3-furyl-3-hydroxyisoindolinones with anilines has\nbeen developed, enabling the divergent construction of chiral spiro-cyclopentenone-isoindolinones\nin high yields with excellent diastereo- and enantioselectivities\neven under a low catalyst loading of 0.5 mol%.