Visible-Light-Induced\nα‑Arylation of\nKetones with (Hetero)aryl Halides

An enamine-mediated photoredox catalyzed C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-coupling of dual radical precursors\nfor the arylation\nof ketone is presented in this Letter. These reactions led to the\nformation of an enamine by using pyrrolidine to functionalize the\nC(sp<sup>3</sup>)–H bond in ketone substrates, which could\nbe smoothly converted to α-arylated ketones with inert aryl\nbromides and even aryl chlorides in moderate to good yields under\nmild reaction conditions. The photocatalytically induced C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-coupling between unactivated\nnoncyclic ketones and aryl halides was achieved, and multiple carbonyl\nα-arylated backbones containing various natural products and\ndrug molecules were successfully constructed.