PhotocatalyticC–H Trifluoroethoxylation of(Hetero)arenes

The trifluoroethoxy group (OCH₂CF₃) is a valuable motif prevalent in pharmaceuticals and agrichemicals. Herein, we present a simple radical trifluoroethoxylation method that enables nondirected functionalization of C–H bonds of a broad array of substrates, providing access to (hetero)aryl trifluoroethyl ethers. The current protocol tolerates a variety of synthetically and pharmacologically relevant functional groups. Applicability is also demonstrated through the late-stage functionalization of biorelevant molecules and marketing drugs.