Preeminent Terminator\nof Oxygen Free RadicalsMineralized\nReduced Water

Drinking water is an essential daily intake to hydrate\nthe body.\nIt is conceivable that water, when endowed with antioxidant properties,\nwill be the most natural radical terminator surpassing conventional\npill-based or food-derived antioxidants. However, current end-of-pipe\npurification of municipal water generally depletes minerals pivotal\nfor antioxidant potency. To surmount this dilemma, we assemble a multistage\nand multifunctional water treatment system using various filter materials\nthat dislodge contaminants, mineralize water and impart reductive\nattributes. The mineralized reduced water (MRW) generated by this\nsystem possesses an ideal antioxidant water quality with weak alkalinity,\nnegative oxidation–reduction potential and rich minerals including\ncalcium, magnesium, zinc and silicon. This water decreases oxidative\nproducts in vivo via counteracting reactive oxygen species and activating\nthe endogenous antioxidant system governed by nuclear factor erythroid\n2-related factor 2. Moreover, long-term intake of MRW effectively\nretards xenografted tumor growth without any discernible hematologic\nand organic toxicity. These findings portend enormous promise for\nMRW in the prevention and treatment of oxidative stress-related maladies\nand even antiaging.