Supplementary files associated with the project "Deep sequencing-derived Metagenome Assembled Genomes from the gut microbiome of liver transplant patients".

Recurrence of metabolic dysfunction-associated steatotic liver disease (MASLD) after liver transplantation (LT) is a continuing concern. The role of gut microbiome dysbiosis in MASLD initiation and progression has been well established. However, there is a lack of comprehensive gut microbiome shotgun sequence data for patients experiencing MASLD recurrence after LT. In this data descriptor, we describe a dataset of deep metagenomic sequences of a well-defined LT recipient population. Community-based analysis revealed a high abundance of <i>Akkermansia muciniphila</i>, consistently observed in most patient samples with a low (0-2) MASLD Activity Score (NAS). We constructed 357 metagenome-assembled genomes (MAGs), including 220 high-quality MAGs (&gt;90% completion). The abundance of different species of <i>Bacteroides</i> MAGs dominated in patient samples with NAS&gt;5 (“definite MASH”). In contrast, the MAGs of <i>A. muciniphila</i>, <i>Akkermansia</i> sp.,<i> </i>and<i> Blutia</i> sp. dominated in samples from patients without MASH (NAS=0-2). In addition, the phylogenetic analysis of <i>A. muciniphila</i> and <i>Akkermansia</i> sp. MAGs identified two new phylogroups of <i>Akkermansia </i>that are distinct from the previously reported three phylogroups<i>.</i>