Lamellodysideol, a new flexible marine norditerpenoid from the Indonesian marine sponge <i>Lamellodysidea herbacea</i>

One new acyclic norditerpenoid, lamellodysideol (<b>1</b>) was isolated from the Indonesian marine sponge <i>Lamellodysidea herbacea</i> together with known phytol (<b>2</b>). The structure of <b>1</b> was determined on the basis of spectral evidence and by comparison with known related molecules including optical rotation data. The relative configurations of <b>1d</b> and <b>2b</b> were proposed using quantum chemical calculation of NMR chemical shifts at DFT levels. In addition, the relative configuration of <b>2b</b> was also supported by Newman’s rule of six and confirmed through Hehre’s protocol. Compounds <b>1d</b> and <b>2b</b> showed toxicity against NBT-T2 cells assay at 10 µg/mL.