Hyper-Resolution Iron Oxide Nanoparticle Templating via Dynamic Self-Assembly and Fractal-Encoded Microfluidic Channels for Targeted Drug Delivery

**Abstract:** This paper details a novel fabrication methodology for creating iron oxide nanoparticles (IONPs) with unprecedented resolution, achieving near-atomic level control over particle morphology and assembly. We introduce Dynamic Self-Assembly Templating (DSAT) coupled with Fractal-Encoded Microfluidic Channel (FEMC) flow, allowing for precise manipulation of nanoparticle precursors within microfluidic environments guided by dynamically adjusted electromagnetic fields. This results in highly uniform, spatially-organized IONP arrays suitable for targeted drug delivery applications, pushing the boundaries of current nanoparticle fabrication techniques and demonstrating potential for significant improvements in therapeutic efficacy and reduced side effects. The resulting nanopatterns can be characterized by a Fractal Dimension (D) approaching 2.7, exhibiting enhanced surface area and tunable magnetic properties.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-08-14
DOI
https://doi.org/10.5281/zenodo.16863404
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
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article

Hyper-Resolution Iron Oxide Nanoparticle Templating via Dynamic Self-Assembly and Fractal-Encoded Microfluidic Channels for Targeted Drug Delivery

Zenodo (CERN European Organization for Nuclear Research)
Nanoparticle-Based Drug Delivery
article

Hyper-Resolution Iron Oxide Nanoparticle Templating via Dynamic Self-Assembly and Fractal-Encoded Microfluidic Channels for Targeted Drug Delivery

article en

Abstract

**Abstract:** This paper details a novel fabrication methodology for creating iron oxide nanoparticles (IONPs) with unprecedented resolution, achieving near-atomic level control over particle morphology and assembly. We introduce Dynamic Self-Assembly Templating (DSAT) coupled with Fractal-Encoded Microfluidic Channel (FEMC) flow, allowing for precise manipulation of nanoparticle precursors within microfluidic environments guided by dynamically adjusted electromagnetic fields. This results in highly uniform, spatially-organized IONP arrays suitable for targeted drug delivery applications, pushing the boundaries of current nanoparticle fabrication techniques and demonstrating potential for significant improvements in therapeutic efficacy and reduced side effects. The resulting nanopatterns can be characterized by a Fractal Dimension (D) approaching 2.7, exhibiting enhanced surface area and tunable magnetic properties.

Zenodo (CERN European Organization for Nuclear Research)
Freed–Hardeman University (US)
Good health and well-being
Openalex Percentile: Top 66%
Nanoparticle-Based Drug Delivery
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