Urtica Dioica: Herbal Nano-gel Comprehensive Approach for Treatment of Pain, Inflammation and Rheumatoid Arthritis

AbstractIn the present scenario, use of herbal medicine has increased many folds on account of side effects as compared toconventional drugs. 70-80% of the world’s population, also the poor nations, are into use of herbal medications forbasic healthcare, because of superior cultural acceptance, slight adverse effects and good compatibility with thehuman body. The purpose of this study is to create and assess a topical nano herbal gel that contains Urtica dioicaessential extracts and metabolites from this plant have been found to possess various pharmacological activities. Oneof such herbs with a long history of anti-inflammatory efficacy is UD; different mechanisms of action have beenunderlined. Several bioactive constituents like flavonoids, fatty acids, sterols, amino acid, phenolic constituents areidentified from nettle plant to date, which are much beneficial for reducing pain, inflammation and RA and produceswound healing effect. In addition to its nutritional value, nettle extracts and their constituents—namely kaempferol,kaempferol-3-O-rutinoside, rutin, quercetin and vitamin A are utilized as antioxidants and anti-inflammatory drugs.In treating pain, inflammation, and rheumatoid arthritis, the topical gel made from ethanol leaves and stem extractof U. dioica may be a safe and effective substitute for non-steroidal anti-inflammatory medications. It also exhibitshigher compliance when compared to other topical formulations. Hence, herbal-based preparations are an importantalternative form of therapy.