Improving Dissolution of Artesunate from Immediate Release Tablet by Inclusion with Beta Β-Cyclodextrin: In Vitro Characterization

This study aimed to use an inclusion complex to increase the solubility of the medication artesunate. The kneading process prepared inclusion complexes of beta cyclodextrins and artesunate. In vitro dissolution tests and saturation solubility analysis were used to assess how the creation of inclusion complexes affected the drug solubility and dissolution. The infrared spectroscopy (IR) method was used to evaluate the complexes. The equimolar quantities of β-cyclodextrin and artesunate in the inclusion complex were then directly compressed into tablets and tested for several in-process quality control parameters. According to saturation solubility experiments, the drug solubility was enhanced by the beta cyclodextrin-PVP-K30 inclusion complex at a molar ratio of 1:2:1. FT-IR demonstrated that inclusion complexes were formed. In contrast to the pure medication, the produced inclusion complex tablets dissolved more quickly. To increase the solubility and dissolution of the poorly soluble medication, Artesunate can be complexed with β-cyclodextrin and PVP-K30.