Therapeutic Evaluation of Nyctanthes Arbor-Tristis on Obsessive Compulsive Disorder

Obsessive compulsive disorder (OCD) is a mental health condition where a person has obsessive thoughts and compulsive activity. OCD can impair all areas of brain functioning and produce devastating effects on patients and their families. Marble-burying behavior of mice is a well-accepted paradigm to screen anti-compulsive activity. The aim of present study was to evaluate the anti-obsessive compulsive effect of Nyctanthes arbor-tristis extract in mice. The present investigation revealed a significant decrease in marble-burying behavior of mice after oral administration of EENAT (200 and 400 mg/kg ) and exhibit anti OCD like effect and the effect of EENAT was comparable to standard anti OCD drug Fluoxetine which also reduce the marble burying behavior in accordance with the previous findings. The maximum effective dose of EENAT was 200mg/kg, at which there was no change in the motor activity. The dose of 400mg/kg also exhibited inhibitory effect on marble burying behavior, but it also reduced the motor activity, hence it is not clear whether the effect of EENAT at 400mg/kg it is due to inhibition of motor activity. .The experimental results of this study shows that ethanolic extract of Nyctanthes arbor-tristis possess anti-obsessive compulsive activities.