A Rare Footprint of TB: Isolated Cuboid Involvement in Skeletal Tuberculosis

Abstract Tuberculosis (TB) continues to be a pressing global health issue, with skeletal involvement accounting for a minor proportion of total cases. TB affecting the foot is particularly uncommon, and isolated involvement of the cuboid bone is exceptionally rare. This report discusses the case of a 21-year-old male presenting with pain and swelling in the dorsolateral region of the left midfoot. A CT-guided biopsy followed by histopathological analysis confirmed necrotizing granulomatous inflammation consistent with Mycobacterium tuberculosis. The patient underwent a six-month regimen of anti-koch therapy (AKT) alongside a strict non-weight-bearing protocol, which led to marked clinical improvement. This case underscores the importance of histopathological verification in diagnosing rare extrapulmonary TB presentations and reinforces the efficacy of current treatment strategies.