Linezolid and Tedizolid: A Solution to Pakistan's Growing Traditional Antibiotic Resistance

Objective: The objective of this study is to observe Linezolid (LZ) and Tedizolid (TZ) activitieson Gram positive bacteria - Staphylococcus aureus, Staphylococcus epidermidis, StreptococcusPneumonia, Enterococcus faecalis, Streptococcus pyogenes, Enterococcus Faecium,Mycobacterium Kansasii, Clostridium difficile Gram-negative bacteria – Escherichia coli,Klebsiella pneumonia, Pseudomonas aeruginosa, and anaerobic bacteria – Bacteroides fragilisthrough disk diffusion method. LZ and TZ are the member of Oxazolidinone which are not verypopular in Pakistan and this study will definitely unveil the activity of Oxazolidinone; WhyOxazolidinone should use in Pakistan in contrast to Gram positive and Gram negative bacteriaparticularly against those bacteria which are resistant to traditional antibiotics.Methods: LZ and TZ discs were employed for the assessment of antibacterial activity of againstGram positive bacteria - Staphylococcus aureus, Staphylococcus epidermidis, StreptococcusPneumonia, Enterococcus faecalis, Streptococcus pyogenes, Enterococcus Faecium,Mycobacterium Kansasii, Clostridium difficile Gram negative bacteria – Escherichia coli,Klebsialla pneumonia, Pseudomonas aeruginosa and Anaerobic bacteria – Bacteroides fragilisThe content of Tedizolid and Linezolid disk was comprised of 2 µg and 30 µg.Results: The antimicrobial susceptibility test described that TZ and LZ were very efficacious incontrast to two isolates of Staphylococcus aureus, Staphylococcus epidermidis, StreptococcusPneumonia, Enterococcus faecalis, Streptococcus pyogenes, Enterococcus Faecium,Mycobacterium Kansasii, Clostridium difficile showed susceptibility (Zone were For found forTZ30mm and 29mm, 23mm and 25mm, 31mm and 28mm, 22mm and 24mm, 25mm and 27mm,21mm and 23mm, 28mm and 26mm, 27mm and 25mm, For LZ 21mm and 25mm, 21mm and20mm, 22mm and 20mm, 19mm and 21mm, 23mm and 22mm, 18mm and 21mm, 22mm and25mm, 13mm and 12mm ), while resistant showed by the two of the isolates of Escherichia coli.