Public summary Deliverable 5.5

While in WP4 of RadicalZ we were focused on the lab-scale optimization of the four reaction systems by using the mathematical modelling approach, in WP5 we were targeting the early-stage evaluation of process economics, i.e., techno-economic analysis. Both approaches create a lot of quantitative data, i.e., metrics, thus, enabling decision making on the further process development. If a targeted reaction system shows to be inefficient, meaning that targeted concentration of the product or volumetric productivity cannot be achieved, then the system can be abandoned, another selected, or better enzyme can be found for further development. The same goes for the economic analysis. Even though the economic estimations at the early stage contain an error, if two systems of the same level are compared, this provides the possibility to decide if the investment will be pursued or not. This is very important for saving resources, and since the cost of process development is very high, it is highly beneficial to stop the development of those that have no potential to succeed early on.As in WP4, in WP5 we were focused on the same four systems, i.e., raspberry ketone synthesis (with ACD), elongation of the sugar parts of acidic sophorolipids (with INSA Toulouse), hirsutanolol synthesis (with ACD) and the synthesis of N-trans-feruloyltyramine (with ACD and UG). Based on the results of model-based process optimization, reaction conditions and reactor mode were selected that enabled obtaining the optimal results. Thus, in this report we summarize the results of the early-stage techno-economic analysis for the above-mentioned systems, bearing in mind the entire process, including the downstream processing part. The results are discussed in comparison to the prices of similar ones, or the same ones, if possible, and recommendations were provided for further development.