Review of: "A Harmless Avian Vaccine Virus Could Be Developed into an Off-the-Shelf "Antibiotic" for Viruses"

The article by Holmes et al. delves into an intriguing approach to antiviral therapy: leveraging viral competition, specificallyviral interference, as a means to combat viral infections. This paper outlines the theoretical and practical foundations ofusing the Infectious Bursal Disease Virus (IBDV) strain R903/78 as a broad-spectrum antiviral. Given the recent surge inzoonotic infections and global pandemic risks, this paper is timely and attempts to bridge the gap between traditionalvaccination and innovative antiviral therapies. The authors argue convincingly that IBDV offers a promising tool forpandemic preparedness, particularly in an era marked by vaccine hesitancy.