Association between Platelet Indices and Risk of Pre- Eclampsia in Pregnant Women: Case Control Study

Abstract Introduction: Pre-eclampsia (PE) is a syndrome characterised by hypertension and proteinuria developing after 20 weeks of gestations. Hypertension is defined as a systolic blood pressure ≥140 mmHg and /or a diastolic blood pressure ≥ 90 mmHg measured at two occasions with at least 6 hours in between. Proteinuria is defined as greater than 300 mg of protein excreted in the urine over 24 hours. Aim: whether there is a significant difference in platelet indices between women who develop pre-eclampsia and those who do not. Methodology: This study is a retrospective case-cotrol hospital-based investigation conducted in the Department of Obstetrics and Gynecology at SP Medical College and associated hospitals in Bikaner, commencing in 2023 and continuing for one year or until the desired sample size is reached. Result: This study found mean platelet count in the control group was 228.73, with a standard deviation of 80.12, while in the case group, the mean platelet count was higher at 288.10, with a standard deviation of 100.60. The mean MPV in the control group was 10.46, with a standard deviation of 2.05, while the case group had a mean MPV of 9.90, with a standard deviation of 2.09. The mean PDW in the control group was 16.85, with a standard deviation of 3.58, while the case group had a mean PDW of 15.05, with a standard deviation of 4.48, suggesting that the difference in PDW between the two groups is very close to statistical significance. Conclusion: The role of platelet indices in pre-eclampsia, suggesting that while platelet count, MPV, PDW, and PCT are important diagnostic markers, their values may vary depending on patient demographics and disease progression.