To Study The Seroprevalance of Torch Infections in Females Exhibiting A Bad Obstetric History

Abstract Background: The term TORCH infections refer to a group of diseases including Toxoplasma, Rubella, Cytomegalovirus (CMV), and Herpes infections. These are a set of pathogens capable of traversing the placental barrier, subsequently causing congenital infections. Often these infections are asymptomatic initially and pose significant diagnostic challenges during gestation, potentially leading to undesirable obstetric outcomes. This research intends to explore the correlation between TORCH infections within pregnancies deemed high-risk. Material and Methods: We included 118 high-risk pregnant patients aged 18-46 from the Obstetrics and Gynecology department of GMC Amritsar. The high-risk group encompassed women with recurring pregnancy loss, fetal congenital anomalies, intrauterine fetal death, and low birth weight intrauterine neonatal death. The presence of IgG and IgM antibodies against TORCH agents in patients’ serum were assessed using ELISA. Results: Among 118 patients, IgM seropositivity was most prevalent for HSV-I infection (40%) followed by HSV-II (38%) Rubella (4.23%), CMV(1.7%) and Toxoplasmosis (1.6%).But based on IgG, seropositivity was most prevalent for Rubella(84%) , followed by CMV (72%) HSV1(57%), Toxoplasma (11.8%)), in women with history of BOH. Co- sero prevalance with multiple TORCH agents i.e. of CMV and Rubella was reported 5.8% (28/118). Significantly, high-risk pregnancies with TORCH seropositivities exhibited a clearly strong correlation with habitual abortions outcomes. Conclusion: High-risk manifestations demonstrated for Toxoplasma gondii, Rubella virus, Cytomegalovirus and Herpes Simplex infections strongly associated with habitual abortions compare to high but less significant association in those seropositive to one, two or three of the TORCH agents