Herbal Ingredients for Sleep Disease Management: Using Vitex Negundo, Chamomile An Comprehensive Review

<p><span>Insomnia, a prevalent sleep disorder characterized by difficulty in initiating and maintaining sleep, adversely affects physical, mental, and emotional well-being. Conventional pharmacological treatments, although effective, are often associated with adverse effects, dependency, and tolerance. These limitations necessitate the development of safer, alternative therapeutic strategies. Nasal drug delivery systems have emerged as a promising approach due to their non-invasive nature, rapid onset of action, and direct access to the central nervous system, bypassing the hepatic first-pass metabolism. This study focuses on the of Vitex negundo and chamomile extracts, both renowned for their sedative and anxiolytic properties. Vitex negundo is rich in flavonoids and essential oils known for their sleep-inducing effects, while chamomile contains apigenin, a bioactive compound that binds to benzodiazepine receptors in the brain, promoting relaxation and sleep. The synergistic combination of these herbal extracts aims to provide a natural and effective solution for insomnia management without the risks associated with synthetic hypnotic. The results revealed optimal physicochemical characteristics suitable for nasal administration, ensuring sustained drug release and prolonged therapeutic effects. Pharmacological evaluations further demonstrated significant sedative activity, supporting the formulation's potential as an effective herbal remedy for insomnia.</span></p>