Thyroid dysfunction in chronic kidney disease patients

ABSTRACT: Background: Thyroid dysfunction is seen in chronic kidney disease patients. It is caused due to multifactorial causes as both kidney disease and thyroid dysfunction are interrelated. In early stages of renal disease due to loss of protein thyroid hormones bounded to proteins lost in urine latter there may be suppression of thyroid axis due to accumulation of various toxins and inflammatory mediators on hypothalamus-pituitary axis. Material and Methods: This study was comprise of 100 patients conducted in G.R.Medical College. Thyroid hormones levels were compared among and correlated with various stages of kidney disease. Observation: Most common thyroid dysfunction seen was low tt3 or tt4 with normal tsh pattern .As the stages of chronic kidney disease progress the thyroid dysfunction increases. The values of total t3 and total t4 increases as the stage progress and tsh values decrease as the stage progress .overt hypothyroidism was seen in advanced chronic kidney disease stage. Conclusion: Thyroid dysfunction significantly increases as the ckd stage progress. Thyroid hormone test should be included in routine investigation in chronic kidney disease patients as symptoms of thyroid dysfunction and uraemia frequency overlap leading to overlooked this condition. Keywords: Thyroid dysfunction, chronic kidney disease, hormones