Acrylamide: Analytical Methods, Toxicity and Regulatory Aspect

The main objective of this study was to formulate and evaluate the oral dispersible tablets of amlodipine besylate with natural and synthetic super disintegrants. Various formulations were prepared by direct compression using different concentrations of natural super disintegrants isolated from fenugreek powder and synthetic super disintegrants namely fenugreek and cross povidone. The drug and excipients compatibility study were performed by FTIR and the study revealed that there evaluated that there was no interaction between drug and excipients. The blend of all formulations was evaluated for various for various precompression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and were found to be satisfactory. The tablets were evaluated for various parameters like weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity, and in vitro drug release. The disintegration time and in vitro drug release of optimized formulation was compared with marketed formulations.