Synthesis and in vitro Evaluation of Novel Thiophene Derivatives

sulfur-containing heterocycles used to create a wide variety of sophisticated compounds with a wide range of biological functions, they are valuable analogs for medicinal chemists. Synthesis novel thiophene derivative by Schiff base were validated by FTIR, MS and 1H-NMR. The produced compounds were additionally assessed for their in vitro biological potentials, specifically antimicrobial activity against chosen microbial species utilizing tube dilution method. Antimicrobial screening outcomes revealed that compound S1 emerged as the most effective antibacterial agent against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella typhi, with an MIC value of 0. 87 µM/ml.