Subcutaneous Panniculitis - Like T-cell Lymphoma: A Tertiary Care Institute Experience

Introduction Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of primary cutaneous lymphoma characterized by cytotoxic alpha-beta T cells, which closely resemble panniculitis. In the latest (5th edition) World Health Organization (WHO) Classification of Tumours of Hematopoietic and Lymphoid Tissues, Subcutaneous Panniculitis-like T-cell Lymphoma (SPTCL) is recognized as a distinct subtype of non-Hodgkin lymphoma [1]. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare condition that can occur in individuals of all ages but is most commonly diagnosed in young adults and middle-aged individuals, with a median age of onset around 36 years. SPTCL primarily affects the subcutaneous fat, presenting as solitary or multiple erythematous nodules and plaques, often localized to the lower extremities but potentially more widespread. Systemic symptoms may include fever, chills, malaise, weight loss, and hepatosplenomegaly.