A Review on In-Vitro Characterization of Remipril Microsphere

Ramipril is a second-generation antihypertensive drug useful in the treatment of hypertention mainly in myocardial infraction which has short plasma half-life of 2-4 hours in adults along with bitter taste and faint odor. Microspheres are suitable drug delivery system for such drug candidate. In the present article endeavor, ramipril microspheres were attempted with a view to reduce the frequency of dosing and to attain steady state drug levels in addition to masking the bitter taste and faint odor of drug. Different batches of ramipril microsphere formulations F1 to F10 were developed using different polymers like eudragit RS-100, eudragit RL-100 and hydroxy propyl methyl cellulose (HPMC) at various ratios. The microspheres were prepared by non-aqueous emulsion solvent evaporation technique. Based on the results of the physicochemical characterization and in vitro drug release studies of all the batches of the formulated microspheres from F1 to F10 formulation F4 was chosen as the most satisfactory formulation as it possessed all the required physicochemical characters and prolonged duration of the drug release up to 24 hours. Scanning electron microscopy studies were showed microspheres are spherical and porous in nature and the drug release was found to be diffusion controlled.