Formulation & Development of Herbal Suppository for Management of UTI by Using Cynodon Dactylon

This study focuses on the formulation and development of an herbal suppository designed for the management of urinary tract infections (UTIs) using Cynodon dactylon extract. The formulation is based on a glycerinated gelatine base prepared by combining glycerine, gelatine powder, and distilled water in defined proportions. Cynodon dactylon, a perennial grass with well-documented ethnomedicinal properties, was processed to obtain extracts through successive solvent extraction and then incorporated into the suppository base. Comprehensive evaluations were performed including phytochemical screening, antimicrobial activity tests, and various physicochemical characterizations such as melting point, disintegration time, weight variation, hardness, softening time, content uniformity, and percentage drug release. Results indicated that the suppositories possess satisfactory physical and chemical properties, with an average melting point around 34°C, a disintegration time of approximately 20 minutes, and nearly 98% drug content uniformity. These findings suggest that the developed herbal suppository could be a promising alternative for UTI management, leveraging both traditional medicinal knowledge and modern pharmaceutical technology.