Synthesis And Characterization of Sphere Like Copper Oxide and Its Electrocatalytic Performance for The Selective Determination of Paracetamol in Biological Samples

Synthesis of nanomaterials for efficiently detecting pharmaceutical medicaments such as paracetamol (PRC) is important for industrial and pharmacological applications. In this study, we prepared copper oxide nanospheres (CuO-NSPs) via facile chemical co-precipitation along with the sonochemical technique. The prepared CuO-NSPs were fabricated on a disposable screen-printed carbon electrode (SPCE) utilized for conducting sensitive and selective electrochemical detection of PRC. The CuO-NSPs were systematically characterized using various spectroscopic techniques, including X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive X-ray analysis, field emission scanning electron microscopy, and Raman spectra. The electrochemical properties of CuO-NSPs were verified using electrochemical impedance spectroscopy (EIS), Cyclic voltammetry (CV) and linear sweep voltammetry techniques. As an electrochemical sensor, the proposed sphere-like copper oxide screen printed carbon electrode (CuO-NSPs/SPCE) demonstrated an excellent sensitivity with a wider linear response range from 0.01 to 1480µM. The electrode also has good sensitivity. Different coexisting compounds were present when the selectivity was tested. Last but not least, the CuO-NSPs/SPCE consistently demonstrates reproducibility, durability, and other critical aspects for future development as a point-of-care device.