Solubilization of Poorly Water-Soluble Drug, Glibenclamide by Micellization with Different Surfactants

Gemini surfactants are a class of self-assembling molecules that consist of two conventionalsurfactants connected via a spacer; they have lower CMC values compared to conventional surfactants, i.e.,having one nonpolar tail and one polar head. In this paper, two series of Gemini surfactants were exploredfor solubilization and thus, improving the bioavailability of a poorly water-soluble drug, i.e., Glibenclamideby micellization. The first series of Gemini surfactants comprises carbohydrate derived conventionalsurfactants, carrying a sugar moiety and the second series comprises nonionic Gemini surfactants withoutsugar moiety, both with varying tail lengths, i.e., C12, C14, C16. It was found that sugar moiety plays a vitalrole in encapsulating the drug molecule in an aqueous medium. By comparison, it was found that the sugarmoiety potentially enhances the aqueous solubility of Glibenclamide. It was also found that with an increasein tail length, the solubility of the drug increased over many folds.own text.