Anticancer Activity of Coleus Amboinicus

Ulcers are most common in the oral region, for which the patient seeks help from their Physician/dental surgeon. The presenting complaints are usually redness, burning, Sensation and/or pain. They can present in any part of the oral cavity but may be painful if it occurs in the movable area. Mouth ulcers cause pain and irritation from salty, spicy, and sour food items and may Cause discomfort while healing occurs due to the use of chemical formulations. This project Focuses on the preparation of an herbal mouth ulcer gel because it has fewer side effects. The gel was prepared by using guava leaf extract, jasmine leaf extract, and peppermint oil. Developed Formulations were transparent and homogeneous, and pH ranged from 6.8 to 7. Formulation Showed applicable spreadability. Therefore, developed formulations have the potential to treat mouth ulcers. However, further clinical studies are required to establish the clinical efficacy of prepared herbal gels. The present research has been undertaken with the objective to formulate and evaluate the polyherbal mucosal gel containing plant extracts (Calendula officinalis and Glycyrrhiza glabra) for the treatment of mouth ulcers. Calendula officinalis and Glycyrrhiza glabra are known to have anti-ulcer, anti-inflammatory, and antibacterial activities. Gels were prepared by using Carbopol. 940P as a gelling agent. Carbopol was used in different concentrations. All the prepared gel Formulations were evaluated for various properties such as pH, spreadability, extrudability, viscosity, in vitro release, etc. The formulation F4 containing a higher concentration (1.4%) of Carbopol 940P as a base showed good adhesion to oral mucosa. FTIR studies showed that there was no drug-excipient interaction. In-vitro drug release studies were carried out in phosphate buffer. (6.8 pH) using a Franz diffusion cell. The results of in vitro drug release and its permeation studies showed that the highest values were from F4, containing Calendula officinalis (91.3% of drug released after 3 hours), and F4 containing Glycyrrhiza Glabra (91.67% of drug released after 3 hour). Stability studies of the F4 formulation were also carried out as per ICH guidelines for 3 months. at different temperature and humidity conditions. Jasminum Officinale L.