COMBINED ANTISEPTIC AND ANTIOXIDANT THERAPY FOR ORAL MUCOSAL INFLAMMATION IN CHRONIC KIDNEY DISEASE PATIENTS: A BIOCHEMICAL AND IMMUNOLOGICAL PERSPECTIVE

Inflammatory diseases of the oral mucosa are common in patients with chronic kidney disease (CKD), often exacerbated by systemic oxidative stress and impaired immune regulation. This study evaluates the effectiveness of a combined therapeutic approach incorporating antiseptic therapy and antioxidant modulation through laser blood irradiation. One hundred CKD patients with oral mucosal inflammation were divided into two groups: the control group received standard symptomatic and antiseptic treatment, while the main group received additional low-level laser blood irradiation and an immunomodulatory antiseptic agent. Biochemical markers, including lipid hydroperoxides (LOOH), catalase activity, and interleukins (IL-1β, IL-2, IL-6), were assessed before and after treatment. The main group showed significant improvements in oxidative stress and cytokine profiles, confirming the superiority of the integrated treatment.