Synthesis and Biological Evaluation of Novel Coumarin Derivatives as Antimicrobial Agents

Coumarin is an organic compound with chemical structure consisting of a benzene ring fused to an alpha-pyrone. Its chemical formula is C9H6O2, featuring two functional groups: an alkene and an ester. Coumarin derivatives are important source of heterocyclic compounds of pharmacological interest, as they show a wide spectrum of biological activity viz antibacterial, antifungal, antiviral, antioxidant, antimalarial, herbicidal, and antitumour activities are exhibited by coumarins. The vast majority of medications are available to treat a wide range of illnesses, but they are not without drawbacks, such as toxicity, resistance, and various adverse effects. The creation of novel chemical entities with greater activity and increased efficacy is required to address these problems. The present study involves in synthesizing four novel coumarin derivatives and characterization of the synthesized derivatives by using Mass, IR and NMR spectras and evaluating the anti-bacterial activity of the prepared compounds.