Effect of Intravenous Infusion of Magnesium Sulphate during Spinal Anesthesia for Inguinal Hernia Repair on Post Operative Analgesia

Abstract Background and aims: IV magnesium sulphate can prolong the effect of spinal anesthesia. The aim is to compare the effect of IV magnesium sulphate during spinal anaesthesia on post-operative pain and regression of motor blockade. Methods: Sample size of 39 in each group. Patients were randomly allocated to two groups. Patients in group M received Inj.MgSO4 50 mg/kg for 15 minutes after spinal anesthesia followed by 15 mg/kg till surgery ends and Group S received same volume of normal saline over same period and observed for time for first analgesia and regression of motor-blockade. Result: Time from spinal anesthesia to first analgesia requirement in Group M was pronged (15.3±2.79). Regression of motor-blockade is delayed in Group M (7.16±1.34). Increase in serum-Magnesium concentration immediately (91.82±0.137), 1 hour (1.90±0.08), 24 hours after surgery (1.80 ±0.07) in Group M. Conclusion: Time for the first t analgesia was prolonged in Group M, and regression of motor blockade was slower in Group M.