PHARMACOLOGICAL EVALUATION OF DIFFERENT EXTRACTS OF LEAVES OF SALACIA FRUTICOSA WALL

The herbal powder that was supplied included alkaloids, carbs, phenols, flavonoids, glycosides, saponins, and terpens in its alcoholic and water-based extracts. Oral administration of an alcoholic and water-based extract of the specified herbal powder at doses of 200 mg/kg and 400 mg/kg body weight for a duration of five days. Carragenan-induced edema is a biphasic response, the first phase is mediated through the release of histamine, serotonin and kinins where as the second phase is related to the release of prostaglandins and mediated by bradykinin, leucotrienes, polymorphonuclear cells and prostaglandins produced by tissue macrophages. Subcutaneous injection of yeast suspension markedly increased the rectal temperature 19 hrs after injection. This type of fever, which is induced by yeast, is called pathogenic fever. Since almost all anti pyretic agents act by inhibiting PG synthesis it is logical to presume that METO and AETO also exerts their effects through the same. Some of the mutant strains of gram –ve rods are used in vaccine preparations (salmonella). The cell wall of this type of bacteria consists of endotoxins (lipoplysaccharides), which activates the macrophages thereby releasing interleukin-1, which causes pyrexia. The results obtained in the present study shown that the Methanolic extract exert concentration or dosed-dependent antinociceptive effects, the rank order of relative potencies in the Eddy’s Hot plate test was :ME>AE. The reaction time was found to be 11.4, and 10.4sec respectively, while the standard drug Tramadol was 11.6sec. The methanol extract shows most significant increased reaction time for mice than Tramadol.