Synchronous Colon Cancer and ALK Positive Lung Cancer

Abstract We present a case of synchronous ALK positive lung cancer and colon cancer. Patient presented to the hospital for routine health checkup and was incidentally detected with both the cancers. Initially it was thought to be colon cancer with lung metastasis. IHC was done on the lung biopsy specimen which was positive for TTF1 and ALK mutation and negative for SATB2. Colon specimen was also reported as mucinous adenocarcinoma histopathologically but IHC was negative for ALK mutation. Hence the diagnosis of synchronous double malignancy was made. Both the cancers were locally advanced without any distant metastasis. Curative resection is done for both the lesions along with targeted therapy for the lung cancer and adjuvant chemotherapy for the colon cancer