POLYMORPHISM OF HLA-DQA1, HLA-DQB1, AND HLA-DRB1 GENES AND THEIR CLINICAL SIGNIFICANCE

This article investigates the polymorphism of HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes and their clinical significance. The study involved 220 blood samples from healthy individuals, with molecular genetic analysis used to identify the alleles of HLA class II genes. The results demonstrated an asymmetric distribution of these alleles. HLA-DQA15*01, HLA-DQB1*02, and HLA-DRB1*07 were identified as the most prevalent alleles. The findings highlight the significance of these results in evaluating immunological compatibility in autoimmune diseases, allergic conditions, and organ transplantation.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-10-31
DOI
https://doi.org/10.5281/zenodo.14015639
Primary Topic
Diabetes and associated disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

POLYMORPHISM OF HLA-DQA1, HLA-DQB1, AND HLA-DRB1 GENES AND THEIR CLINICAL SIGNIFICANCE

Zenodo (CERN European Organization for Nuclear Research)
Diabetes and associated disorders
article

POLYMORPHISM OF HLA-DQA1, HLA-DQB1, AND HLA-DRB1 GENES AND THEIR CLINICAL SIGNIFICANCE

article en

Abstract

This article investigates the polymorphism of HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes and their clinical significance. The study involved 220 blood samples from healthy individuals, with molecular genetic analysis used to identify the alleles of HLA class II genes. The results demonstrated an asymmetric distribution of these alleles. HLA-DQA15*01, HLA-DQB1*02, and HLA-DRB1*07 were identified as the most prevalent alleles. The findings highlight the significance of these results in evaluating immunological compatibility in autoimmune diseases, allergic conditions, and organ transplantation.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 63%
Diabetes and associated disorders
DOIOpen Access PDFOpenAlex
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POLYMORPHISM OF HLA-DQA1, HLA-DQB1, AND HLA-DRB1 GENES AND THEIR CLINICAL SIGNIFICANCE · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS