Guava Leaf Extract as a Natural Therapeutic Agent in Aphthous Ulcer Management: A Comprehensive Review

Aphthous ulcers, or canker sores, are painful, recurrent lesions that significantly affect quality of life. Despite being self-limiting, the condition often demands therapeutic management due to pain, interference with daily functions, and recurrence. Conventional treatments such as topical corticosteroids, antiseptics, and immunomodulators come with side effects or cost limitations. Guava (Psidium guajava) leaves, traditionally used in herbal medicine, offer a natural and effective alternative with antimicrobial, anti-inflammatory, antioxidant, and wound-healing properties. This review evaluates the scientific basis and therapeutic potential of guava leaf extract in managing aphthous ulcers, emphasizing its advantages over conventional treatments, pharmacological mechanisms, and future prospects.