Formulation and Evaluation of Sustained Release Matrix Tablet of Efavirenz

In this study, matrix tablets of efavirenz were made using the direct compression method, which is currently thought to be a straightforward and economical manufacturing process. It is regarded as a suitable technique for compounds that are thermolabile and hygroscopic. A total of six formulations with varying amounts of polymers were created. Using a Monsanto hardness tester, the average hardness values were determined for each composition. From each formulation, twenty tablets were chosen at random and examined. Nearly consistent data were collected. Since the percentage of weight variation was within the USP Pharmacopoeia's bounds of ±5% of the weight, all of the tablets passed the weight variation test. All of the prepared tablets' drug contents were found to be within the acceptable range. The findings that fall within the range show that the mixing is uniform.