Curcumin and Nanocurcumin Lowers the Methyl Nitroso-Urea (MNU) Induced Neoplasia with Renal Injury in Rats via Modulation of Oxidative Stress Molecular Pathways

Introduction: MNU induced tumor burden and oxidative stress or toxicity on kidney functions in kidney tissues of male rats was prevented and protective role of nanocurcumin was explored in MNU induced neoplasia with nephrotoxicity. Methods: A total of thirty-six adult male rats were divided into six groups for the study. Nanocurcumin (oral administration 100 mg/kg) or no nanocurcumin was given to the MNU (2 mg/kg) and control groups. After 7 days of treatment, renal parameters, oxidative stress biomarkers and expression level of sirtuins1 (SIRT1)/Fork head box protein O1 (FoxO1) pathway genes were evaluated in renal tissues. In addition, histopathological changes in the renal tissues were assayed. Results: In MNU group compared to control group, levels of lipid peroxidation, urea and creatinine were increased, total antioxidant capacity and thiol groups decreased significantly P<0.05. In nanocurcumin groups compared to MNU group, lipid peroxidation and creatinine levels were reduced meaningfully P<0.05. Also, nanocurcumin banned the tissue damage produced by MNU. Nanocurcumin modulated the effect of MNU on the gene expression levels in SIRT1/FoxO1 protein. Conclusion: The results of present study established that MNU neoplastic effect initially can trigger oxidative stress pathway in kidney tissues to induce oxidative damage. Nanocurcumin anti-oxidative stress as potential antioxidant with antineoplastic therapy can be effective in therapeutics of neoplastic nephrotoxicity.