Alpha amylase and Alpha glucosidase Enzymes inhibitory assay of newly synthesized zinc complexes

Abstract: A total of five Zinc(II) complexes of 2-(2-Methoxyphenoxy)acetic acid were prepared by using Methyl alcohol as a solvent, in the absence (C1), and in the presence of pyridine (C2), 3-Methyl pyridine (C3), 1,10-phenanthroline (C4) and 2,2′-bipyridine (C5). Moderately good yields of the complexes were obtained. The synthesized compounds were characterized by FT-IR and UV-Visible spectrophotometry. Complexes showed inhibition activity towards Alpha-amylase and Alpha- glucosidase enzymes. Their increasing order of activity in Alpha-amylase inhibition was C5 > C3 > C1 > C2 > C4 > C and that of Alpha-glucosidase inhibition C4 > C2 > C > C3 > C1 > C5.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-10-26
DOI
https://doi.org/10.5281/zenodo.14001039
Primary Topic
Natural Antidiabetic Agents Studies
Type
article
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article

Alpha amylase and Alpha glucosidase Enzymes inhibitory assay of newly synthesized zinc complexes

Zenodo (CERN European Organization for Nuclear Research)
Natural Antidiabetic Agents Studies
article

Alpha amylase and Alpha glucosidase Enzymes inhibitory assay of newly synthesized zinc complexes

article en

Abstract

Abstract: A total of five Zinc(II) complexes of 2-(2-Methoxyphenoxy)acetic acid were prepared by using Methyl alcohol as a solvent, in the absence (C1), and in the presence of pyridine (C2), 3-Methyl pyridine (C3), 1,10-phenanthroline (C4) and 2,2′-bipyridine (C5). Moderately good yields of the complexes were obtained. The synthesized compounds were characterized by FT-IR and UV-Visible spectrophotometry. Complexes showed inhibition activity towards Alpha-amylase and Alpha- glucosidase enzymes. Their increasing order of activity in Alpha-amylase inhibition was C5 > C3 > C1 > C2 > C4 > C and that of Alpha-glucosidase inhibition C4 > C2 > C > C3 > C1 > C5.

Zenodo (CERN European Organization for Nuclear Research)
International Islamic University, Islamabad (PK), Abdul Wali Khan University Mardan (PK), University of Swat (PK), Department of Mathematical Sciences (RU), University of Swabi (PK), University of Malakand (PK)
Clean water and sanitation
Openalex Percentile: Top 54%
Natural Antidiabetic Agents Studies
DOIOpen Access PDFOpenAlex
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Alpha amylase and Alpha glucosidase Enzymes inhibitory assay of newly synthesized zinc complexes · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS