CHITOSAN-BASED NANOFIBERS: SYNTHESIS OF AN INNOVATIVE BIOMATERIAL

This review article presents a comprehensive analysis of global scientific research results in the field of chitosan-based nanofibers over the past decade (2015-2025). Recent achievements in chitosan nanofiber preparation methods, particularly electrospinning and mechanical processing technologies, are examined in detail. The article analyzes the physicochemical, mechanical, thermal, and electrical properties of chitosan nanofibers, as well as the distinctive characteristics of their composites with metal nanoparticles (silver, gold, copper, iron oxide). The potential applications of chitosan nanofibers in the biomedical and pharmaceutical fields, including drug delivery systems, tissue engineering, wound healing treatments, and antimicrobial applications, are highlighted. Additionally, innovative directions from 2020-2025 such as smart multifunctional systems, integration with 3D bioprinting technologies, neurological applications, and industrial-scale production prospects are discussed. The presented data demonstrates the potential of chitosan nanofibers as next-generation biomaterials to make significant contributions to improving patient outcomes across various medical fields.