Nanocochleates: A Novel Platform in Delivery Therapeutic Cargo

This review article explores the exciting potential of nanocochleates as a novel drug delivery platform. Lipid-based drug delivery (LDDs) systems attract increasing interest in the pharmaceutical industry due to their advantages in solubility and bioavailability of poorly water-soluble drugs. Nanocochleates are the lipid based multi-layered spiral structure that resemble a small shell-like structure which is achieved through the interaction of negatively charged lipid and positively charged calcium ions which causes lipid bilayer to roll into cochlear-like structure. Due to these structures nanocochleates can encapsulate drugs in their hydrophobic structure while keeping them in a stable protected form. The structure of nanocochleates is highly stable, making them protected from harsh environmental conditions such as pH and enzymatic degradation. The nanocochleates can deliver a wide range of therapeutic agents inc. small molecules peptides, proteins and nucleic acid. Due to their unique property nanocochleates are being explored in various medical applications inc. Cancer therapy, vaccine delivery, anti-inflammatory treatment and gene therapy. Nanocochleates represents a promising platform in the field of nanomedicine and drug delivery, providing innovative solutions for effective and targeted therapy. This comprehensive overview aims to provide a thorough understanding of the current landscape and future prospects of nanocochleates in the field of drug delivery.