Formulation and Characterization of Multiple Emulsion for Enhanced Drug Delivery and Therapeutic Applications: A Review

Many uses for emulsions have been suggested, such as improving bioavailability or acting as a sustained drug delivery method. However, before they can be used in pharmaceuticals, the system's essential instability must be resolved. Hydrophilic and hydrophobic surfactants are frequently used in combination to stabilise multiple emulsions. Achieving stable multiple emulsions depends on the ratio of these surfactants. was chosen as a model drug for studying the possibility of using several emulsions to increase bioavailability, with the idea that an improvement in the drug's release profile would correlate with an increase in its bioavailability. The aim of this research was to create many emulsions using two-step emulsification using various non ionic surfactants, Tweens and Spans, and assess stability, drug entrapment percentage, and in vitro drug release. The study arrived at the conclusion that a two-step emulsification approach combining Spans20,40, 60, and 80 as primary emulsifiers and Tween80 as secondary emulsifiers and cosurfectant like Peg400,use can produce stable multiple emulsions with good entrapment efficiency.