Automated Parameter Optimization and Control of Granular Fluidization Dynamics for Enhanced Coating Uniformity via Reinforcement Learning

**Abstract:** This research details the development and implementation of a Reinforcement Learning (RL) agent for real-time, automated optimization of key process parameters within fluid bed coating systems. By leveraging a custom-built physics-informed simulation environment and advanced multi-modal data sensing, the agent dynamically adjusts gas flow rate, spray nozzle position, and coating solution delivery rate to achieve unprecedented coating uniformity and efficiency in the production of pharmaceutical granules. This system, exceeding current manual and pre-programmed control methods, showcases immediate commercial potential within the pharmaceutical and food processing industries.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-08-08
DOI
https://doi.org/10.5281/zenodo.16777019
Primary Topic
Granular flow and fluidized beds
Type
article
Field-Weighted Citation Impact
0.00
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article

Automated Parameter Optimization and Control of Granular Fluidization Dynamics for Enhanced Coating Uniformity via Reinforcement Learning

Zenodo (CERN European Organization for Nuclear Research)
Granular flow and fluidized beds
article

Automated Parameter Optimization and Control of Granular Fluidization Dynamics for Enhanced Coating Uniformity via Reinforcement Learning

article en

Abstract

**Abstract:** This research details the development and implementation of a Reinforcement Learning (RL) agent for real-time, automated optimization of key process parameters within fluid bed coating systems. By leveraging a custom-built physics-informed simulation environment and advanced multi-modal data sensing, the agent dynamically adjusts gas flow rate, spray nozzle position, and coating solution delivery rate to achieve unprecedented coating uniformity and efficiency in the production of pharmaceutical granules. This system, exceeding current manual and pre-programmed control methods, showcases immediate commercial potential within the pharmaceutical and food processing industries.

Zenodo (CERN European Organization for Nuclear Research)
Freed–Hardeman University (US)
Zero hunger
Openalex Percentile: Top 54%
Granular flow and fluidized beds
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