Kaempferol's pharmacological effects on strychnine-induced convulsions in lab mice (Albino mice)

Historical background of epilepsy The word epilepsy is derived from Greek word Epilambane in and means to seizure upon or to taking hold of or to take over. Epilepsy is a chronic neurological disorder, with a prevalence of about 1%, which is characterized by the recurrent appearance of spontaneous seizures due to neuronal hyperactivity in the brain (Dell;1986) Whitman S, 01 Definition of epilepsy Epilepsy is a chronic neurological disorder, with a prevalence of about 1%, which is characterized by the recurrent appearance of spontaneous seizures due to neuronal hyperactivity in the brain In 2005, a Task Force of the International League against Epilepsy (ILAE) formulated conceptual and operational definitions of “seizure” and “epilepsy” Conceptual Definition of Seizure and Epilepsy – 2005 Report An epileptic seizure is a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures, and by the neurobiological, cognitive, psychological, and social consequences of this condition. The definition of epilepsy requires the occurrence of at least one epileptic seizure.