Azithromycin: A Pharmaceutical Studies & Mechanisms of Action

Azithromycin is a broad-spectrum macrolide antibiotic widely used to treat various bacterial infections, including respiratory, enteric, and genitourinary infections. Pharmaceutical studies on azithromycin focus on its formulation, pharmacokinetics, bioequivalence, and therapeutic efficacy. Research has been conducted to develop stable and globally acceptable tablet formulations, considering factors like lubricants, wetting agents, and binders. Additionally, bioequivalence studies compare different formulations of azithromycin tablets under fasting and fed conditions. Azithromycin has also been studied for its potential antiviral activity and its use in treating COVID-19, where it showed promising results in combination with hydroxychloroquine in early studies. The development of analytical techniques, such as reverse-phase high-performance liquid chromatography (RP-HPLC), has been crucial for the simultaneous estimation of azithromycin and other antibiotics like cefixime in bulk and pharmaceutical formulations.