Evaluation of Wound healing activity of leaves of Passiflora foetida L in Streptozotocin-induced diabetes mellitus and Diabetic Excision Model

Abstract— The present study aimed to evaluate the wound healing activity of the leaves of Passiflora foetida L. in Streptozotocin (STZ)-induced diabetes mellitus in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/Kg) in Wistar albino rats after overnight fasting. The diabetic rats were subjected to excision wounds on the dorsal side, which were treated with varying doses (100, 200, and 400 mg/Kg) of ethanol and ethyl acetate extracts of Passiflora foetida leaves for 21 days. The wound healing parameters, including wound contraction rate, epithelialization time, and scar area, were monitored and compared with the control group and standard treatment (Metformin 5 mg/Kg). The results revealed that both ethanol and ethyl acetate extracts exhibited significant wound healing activity, with the ethyl acetate extract (400 mg/Kg) showing the most potent effect. The extracts significantly enhanced wound closure, reduced epithelialization time, and promoted granulation tissue formation. The findings suggest that Passiflora foetida leaves possess substantial wound healing properties and could be a potential therapeutic candidate for the management of diabetic wounds.