A NOVEL BIOMATERIAL C-PRF FOR POCKET REDUCTION- A SPLIT MOUTH RANDOMIZED CLINICAL TRIAL

Background : This split mouth randomized clinical trial aimed to assess the clinical efficacy of C-PRF as an adjunct to scaling and root planning (SRP) in stage III with grade A/B periodontitis. Platelet concentrates, of which the last is concentrated-platelet rich fibrin (C-PRF) have a tenfold increase in the platelets in the buffy coat, eventually degranulating to a higher growth factor release rate. So the novel biomaterial obtained from blood will be used in enhancing the effectiveness of SRP through its adjunctive use in treating periodontal disease. Methods: A total of 96 sites from 48 patients were included in the study. Baseline clinical parameters were recorded, followed by a complete full-mouth SRP. The test and control sites were randomly selected, and intra-pocket application of C-PRF was carried out at the test site and the parameters were reassessed after 6 weeks with P <0.05. Results: The test group had a mean reduction in pocket probing depth, relative attachment level, plaque Index, gingival index and modified sulcular bleeding index in comparison to the control group at 6 weeks. From baseline to 6 weeks, improvement in the parameters was seen in the test group in comparison to the control group. Conclusion: This study emphasizes that C-PRF can be one of the promising modalities for practicing clinicians in treating periodontal pockets with evident reduction in inflammation.