Emulgels: Revolutionizing Topical and Transdermal Drug Delivery

Emulgels are a groundbreaking hybrid drug delivery system that combines the solubility-enhancing benefits of emulsions with the controlled-release properties of gels. This biphasic formulation excels in topical and transdermal applications, enhancing drug stability, bioavailability, and skin permeation for both hydrophilic and lipophilic active pharmaceutical ingredients. Emulgels provide sustained release, improved patient compliance, and reduced systemic side effects compared to traditional creams, ointments, and gels. This review offers a comprehensive exploration of emulgel composition, drug release mechanisms, formulation strategies, and therapeutic applications, emphasizing their role in dermatological, anti-inflammatory, and cosmeceutical fields. It highlights cutting-edge innovations such as nano-emulgels, stimuli-responsive systems, and 3D-printed formulations while addressing challenges like formulation complexity and regulatory hurdles. Future directions focus on personalized medicine, nanotechnology integration, and sustainable production to propel emulgel technology forward.