Cataract Management: Bridging The Gap Between Surgical Interventions and Emerging Non- Invasive Treatments

One of the most common causes of preventable blindness in the world today is cataract, and its incidence is projected to double in next two decades. Antioxidative stress, protein aggregation and low ion homeostasis: a review on the pathogenesis and treatment of cataract is the current one. The paper specifies the criticality of effective pharmacological and non-pharmacological cures for the prevention, postponement or remission of cataracts considering the restrictions posed by surgical techniques.The research investigates different topical approaches for preventing cataract, from antioxidants to aldoses reductase inhibitors and anti-proteinaggregates therapy studies. It also outlines the significance of dietary and lifestyle modifications to prevent cataract. Further, the review provides insights into recent advances in nanomedicine-based drug delivery systems for cataract therapy, stem cell–based lens regeneration and the use of AI and ML for cataract diagnosis and drug discovery.Natural compounds with anti-cataract potential are summarized followed by a comparative analysis of herbal extracts and synthetic drugs in this study, and the output is consequently promising for some.Finally, the paper ends with challenges and constraints in anti-cataract therapies to date, underlining the importance of future research and development for this kind.