THE ROLE OF 24-HOUR AMBULATORY BLOOD PRESSURE MONITORING IN THE ASSESSMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH ULCERATIVE COLITIS

Abstract Cardiovascular diseases, including atherosclerosis and arterial hypertension, are a priority for the World Health Organization. Indeed, cardiovascular disease is the leading cause of death, accounting for one third of deaths worldwide. A growing body of evidence shows that the pathogenesis of hypertension is closely linked to dysbiosis of the intestinal microbiota. When the intestinal barrier function is normal and intestinal permeability is low, it can effectively prevent the leakage of intestinal pathogens, enteroendotoxins and other substances into the body, thus reducing acute and chronic inflammation in all organs. Ulcerative colitis, which is an inflammatory bowel disease, is believed to occur in people with a genetic predisposition after exposure to environmental factors; defects in the intestinal epithelial barrier, changes in the microbiota and dysregulation of the immune response. Given the relevance of the topic, this article describes the mechanisms that affect the intestinal microbiota in patients with hypertension and ulcerative colitis, as well as the 24-hour ambulatory blood pressure monitoring to understand the cause of high blood pressure in patients with ulcerative colitis.