Evaluation Of Antiulcer Activity of Ativisha by Ethanol Induced Model on Experimental Animal

The present study investigates the antiulcer activity of the ethanolic root extract of Aconitum heterophyllum (ERAH) in ethanol-induced ulcer models in albino Wistar rats. The study aimed to evaluate the ulcer index, ulcer score, and other related parameters such as pH, free acidity, and total acidity following the administration of different doses of ERAH (225 mg/kg, 450 mg/kg, and 900 mg/kg) and comparison with the standard drug Omeprazole (20 mg/kg). The findings revealed that ERAH demonstrated significant protection against ulcer formation, with a dose-dependent reduction in ulcer scores and ulcer indices. The highest dose of 900 mg/kg showed a notable inhibition of ulcer formation (20.48%) compared to the control group. Additionally, ERAH treatment resulted in a significant improvement in gastric pH and a reduction in both free and total acidity levels. These results suggest that Aconitum heterophyllum has promising antiulcer properties and may offer an alternative therapeutic approach for the treatment of gastric ulcers.