Acute oral toxicity assessment of ethanolic extract of Cassia auriculata linn whole plant in Albino mice

Abstract : The current study was conducted to assess the safety of an ethanol extract of the Cassia auriculata linn entire plant by detecting its potential toxicity following acute administration in Swiss albino mice. For the acute investigation, an ethanol extract of Cassia auriculata linn entire plant was supplied to albino mice in a single dose of 0-2000 mg/kg via feeding. After feeding, behavioral changes, adverse effects, and death were assessed for up to 14 days. Histopathological examinations were performed 14 days following oral dosing. At the end of the observation period, animals were sacrificed. In an acute investigation with ethanol extract of Cassia auriculata linn, the whole plant showed no behavioral alterations indicating detrimental effects or deaths. There were no significant differences in organ weights or gross necropsy between the treatment and control groups. The ethanol extract of Cassia auriculata linn entire plant can be deemed relatively harmless at the oral dose tested because it did not induce any mortality or unfavorable behavioral changes in albino mice, according to a necropsy investigation in acute toxicity.