FORMULATION AND EVALUATION OF NIFEDIPINE TRANSDERMAL DRUG DELIVERY SYSTEMS

The aim of this present research work is to formulate and evaluate transdermal patches using Nifedipine. At present Nifedipine is available as tablets in the market. Patients are non-cooperative to these dosage forms. Hence transdermal drug delivery system has started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. The λmax of Nifedipine in 7.4pH phosphate buffer solution was found to be 229nm. The objective of the study is to design and evaluation of Nifedipine transdermal patches using polymers such as HPMC K 15M, HPMC K 100Mand HPMC K200M. The preparation of Nifedipine transdermal patches by solvent casting method. In-vitro skin permeation studies were performed by using a Franz diffusion cell with a receptor compartment capacity of 22.5 mL. The amount of plasticizer tween 80 was critical for patch formation and separation properties. Tween 80 was selected for solubility enhancer and plasticizer during shelf-life period. It was concluded that formulations F-5 was found to be satisfactory batch and was optimized for the desirable properties. Keywords: Nifedipine, transdermal patches, Franz diffusion cell, Tween 80.